![]() Recent cell culture and in vivo rat studies have indicated that Cr(pic)(3) probably generates oxidative damage of DNA and lipids and is mutagenic, although the significance of these results on humans taking the supplement for prolonged periods of time is unknown and should be a focus for future investigations. However, over a decade of human studies with Cr(pic)(3) indicate that the supplement has not demonstrated effects on the body composition of healthy individuals, even when taken in combination with an exercise training programme. Additionally, claims have appeared that the supplement might give rise to deleterious effects. Cr(pic)(3) has been amazingly popular with the general public, especially with athletes who may have exercise-induced increased urinary chromium loss however, its effectiveness in manifesting body composition changes has been an area of intense debate in the last decade. Because the supplement is absorbed better than dietary chromium, most studies have focused on the use of chromium picolinate. As this role probably involves potentiation of insulin signalling, chromium dietary supplementation has been postulated to potentially have effects on body composition, including reducing fat mass and increasing lean body mass. ![]() ![]() The element chromium apparently has a role in maintaining proper carbohydrate and lipid metabolism in mammals.
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